Effect of molecular size on permeability coefficients in human dentine

D. H. Pashley, M. J. Livingston

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The effect of increasing molecular radius on the rate of permeation of human dentine discs was determined. The substances tested were water, urea, fluoride, lidocaine, glucose, sucrose, inulin, dextran, polyvinylpyrrolindone and albumin. A 19-fold increase in molecular radius from 1.9 Å (3H2O) to 37 Å (131I-albumin) resulted in a 100-fold decrease in permeability coefficients calculated by the Fick equation. Acid-etching the dentine produced a 4-fold increase in 3H2O permeability and a 9-fold increase in 131I-albumin permeability. Both fluoride and chlorhexidine permeabilities were much lower than expected for their molecular weight or size, suggesting that they are bound to dentine. It is concluded that dentine permeability is determined, in part, by the nature of the dentine surface.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalArchives of Oral Biology
Issue number5
StatePublished - 1978

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology


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