Effect of oral estrogen on substrate utilization in postmenopausal women

Rebecca Lwin, Betty Darnell, Robert Oster, Jeannine Lawrence, Jill Foster, Ricardo Azziz, Barbara A. Gower

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We tested the hypothesis that a 2-month intervention with unopposed oral conjugated equine estrogens (0.625 mg/d) would decrease lipid oxidation, as assessed by 24-hour, whole-room, indirect calorimetry in 14 postmenopausal women. Estrogen (E) treatment was associated with declines in both 24-hour and postprandial lipid oxidation and an increase in fat mass (mean [±SD] 2-month difference 1.1 ± 1.0 kg; mean 6-month difference 1.8 ± 2.2 kg), suggesting that, on an acute basis, oral E may increase adiposity by limiting lipid oxidation.

Original languageEnglish (US)
Pages (from-to)1275-1278
Number of pages4
JournalFertility and sterility
Issue number4
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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