Effect of perfusion and blood content on ultrasonic backscattering of liver tissue

Hiroshi Kimitsuki, Richard E. Parsons, Bernard Sigel, Ernest J. Feleppa, Robert M. Golub, Jeffery Justin, Junji Machi, Mary Rorke, Joan Sokil-Melgar, Issei Kodama, Toshihiko Kurohiji, Teruo Kakegawa, Howard A. Zaren

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The purpose of this study was to determine the effect of blood flow perfusion and red cell content on ultrasonic scattering by liver tissue. Data acquisition for ultrasonic tissue characterization (UTC) employing analysis of the backscattered echoes from the power spectrum was obtained from the same region of pig liver tissue under four conditions: 1) normal perfusion in situ, 2) ischemia in situ in the living pig, 3) ischemia in situ immediately postmortem, and 4) immediately after excision of the liver. Discriminant function analysis was used to evaluate differences in the two basic parameters from the normalized power spectrum: slope and intercept. Normal perfused liver had significantly higher intercept values and lower slope values than liver under the other three conditions. Excised liver showed the lowest intercept and highest slope values (p < 0.01). These experiments indicate that differences in perfusion produce significant differences in ultrasonic scattering by liver tissue (ischemia caused a 3 dB drop in intercept amplitude). Normal or ischemic in vivo and in vitro liver tissue is associated with different patterns of ultrasonic scattering, and scattering data under these various circumstances are not equivalent.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalUltrasound in Medicine and Biology
Issue number1
StatePublished - 1993
Externally publishedYes


  • Backscattering from perfused and nonperfused liver tissue
  • In vivo and in vitro scattering
  • Perfusion of liver tissue
  • Power spectrum analysis
  • Ultrasonic backscattering from liver tissue
  • Ultrasonic tissue characterization

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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