Abstract
Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg-1, p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.
Original language | English (US) |
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Pages (from-to) | 906-911 |
Number of pages | 6 |
Journal | Fitoterapia |
Volume | 72 |
Issue number | 8 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Cyclophosphamide
- Mitomycin-C
- Protective effects
- Spirulina fusiformis
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery