Effect of target-enriched multiplex polymerase chain reaction on patient outcomes and costs during the 2013–14 influenza season

A. Hassoun; M. D. Huff; E. Asis; K. Chahal; A. Azarbal; S. Lu

doi:10.1016/j.jhin.2017.04.010

Effect of target-enriched multiplex polymerase chain reaction on patient outcomes and costs during the 2013–14 influenza season

A. Hassoun
, M. D. Huff
, E. Asis
, K. Chahal
, A. Azarbal
, S. Lu

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation. Patients negative for H1N1 via TEM-PCR had antiviral therapy immediately stopped, thereby evading 408 days of oseltamivir and 315 days of unnecessary isolation. This cost avoidance saved US$208,982.

Original language	English (US)
Pages (from-to)	366-370
Number of pages	5
Journal	Journal of Hospital Infection
Volume	96
Issue number	4
DOIs	https://doi.org/10.1016/j.jhin.2017.04.010
State	Published - Aug 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimicrobial stewardship
H1N1
Hospitalization cost reduction
Influenza
Multiplex PCR
Oseltamivir

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.jhin.2017.04.010

Cite this

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title = "Effect of target-enriched multiplex polymerase chain reaction on patient outcomes and costs during the 2013–14 influenza season",

abstract = "The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7\% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation. Patients negative for H1N1 via TEM-PCR had antiviral therapy immediately stopped, thereby evading 408 days of oseltamivir and 315 days of unnecessary isolation. This cost avoidance saved US\$208,982.",

keywords = "Antimicrobial stewardship, H1N1, Hospitalization cost reduction, Influenza, Multiplex PCR, Oseltamivir",

author = "A. Hassoun and Huff, \{M. D.\} and E. Asis and K. Chahal and A. Azarbal and S. Lu",

note = "Publisher Copyright: {\textcopyright} 2017 The Healthcare Infection Society",

year = "2017",

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doi = "10.1016/j.jhin.2017.04.010",

language = "English (US)",

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TY - JOUR

T1 - Effect of target-enriched multiplex polymerase chain reaction on patient outcomes and costs during the 2013–14 influenza season

AU - Hassoun, A.

AU - Huff, M. D.

AU - Asis, E.

AU - Chahal, K.

AU - Azarbal, A.

AU - Lu, S.

PY - 2017/8

Y1 - 2017/8

N2 - The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation. Patients negative for H1N1 via TEM-PCR had antiviral therapy immediately stopped, thereby evading 408 days of oseltamivir and 315 days of unnecessary isolation. This cost avoidance saved US$208,982.

AB - The US Centers for Disease Control and Prevention recommends the initial use of rapid antigen influenza diagnostic test (RIDT) for the detection of influenza A (H1N1-09). Nasopharyngeal samples were tested from 246 patients for H1N1-09 using target-enriched multiplex polymerase chain reaction (TEM-PCR), of which 163 were additionally tested via RIDT. RIDTs had a sensitivity of 18.7% compared with TEM-PCR as the reference standard. Patients with false-negative RIDTs were withheld from 111 days of oseltamivir and 65 days of isolation. Patients negative for H1N1 via TEM-PCR had antiviral therapy immediately stopped, thereby evading 408 days of oseltamivir and 315 days of unnecessary isolation. This cost avoidance saved US$208,982.

KW - Antimicrobial stewardship

KW - H1N1

KW - Hospitalization cost reduction

KW - Influenza

KW - Multiplex PCR

KW - Oseltamivir

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UR - https://www.scopus.com/pages/publications/85019693912#tab=citedBy

U2 - 10.1016/j.jhin.2017.04.010

DO - 10.1016/j.jhin.2017.04.010

M3 - Article

C2 - 28571763

AN - SCOPUS:85019693912

SN - 0195-6701

VL - 96

SP - 366

EP - 370

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

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ER -

Effect of target-enriched multiplex polymerase chain reaction on patient outcomes and costs during the 2013–14 influenza season

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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