TY - JOUR
T1 - Effects of biogenic amines, FMRFamide and acetylcholine on the radula protractor muscle of a whelk
AU - Nagle, Gregg T.
AU - Greenberg, Michael J.
N1 - Funding Information:
Acknowledqements--This work was supported by NIH grant HL-09283 to M.J.G. and is Contribution No. 169 from the Tallahassee, Sopchoppy & Gulf Coast Marine Biological Association. We thank Dr David A. Price and Dr S. D. Painter for helpful suggestions during the course of this work, and Dr Robert B. Hill for critical reading of the manuscript.
PY - 1982
Y1 - 1982
N2 - 1. 1. The muscle was isolated from the southern whelk, Busycon contrarium. 2. 2. Dopamine (DA) elicits a single phasic contraction that is rapidly desentisized at high drug concentrations. Such desensitized preparations still respond to acetylcholine (ACh) and the molluscan neuropeptide FMRFamide. The evidence suggests the existence of an excitatory DA receptor. 3. 3. Muscles in FMRFamide or ACh contraction are relaxed by 5-hydroxytryptamine, phenylethylamines and catecholamines in a dose-dependent manner; a single phasic contraction precedes the catecholamine relaxation of such muscles. 4. 4. The responsesto FMRFamide, ACh and DA are sodium dependent; FMMFamide responses are more calcium dependent than ACh or DA.
AB - 1. 1. The muscle was isolated from the southern whelk, Busycon contrarium. 2. 2. Dopamine (DA) elicits a single phasic contraction that is rapidly desentisized at high drug concentrations. Such desensitized preparations still respond to acetylcholine (ACh) and the molluscan neuropeptide FMRFamide. The evidence suggests the existence of an excitatory DA receptor. 3. 3. Muscles in FMRFamide or ACh contraction are relaxed by 5-hydroxytryptamine, phenylethylamines and catecholamines in a dose-dependent manner; a single phasic contraction precedes the catecholamine relaxation of such muscles. 4. 4. The responsesto FMRFamide, ACh and DA are sodium dependent; FMMFamide responses are more calcium dependent than ACh or DA.
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U2 - 10.1016/0306-4492(82)90160-5
DO - 10.1016/0306-4492(82)90160-5
M3 - Article
AN - SCOPUS:0020376572
SN - 0306-4492
VL - 73
SP - 17
EP - 21
JO - Comparative Biochemistry and Physiology. Part C, Comparative
JF - Comparative Biochemistry and Physiology. Part C, Comparative
IS - 1
ER -