Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

U. Frey, Y. Y. Huang, E. R. Kandel

Research output: Contribution to journalArticlepeer-review

1032 Scopus citations


Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism for the establishment of certain forms of explicit memory in the mammalian brain. As is the case with behavioral memory, LTP in the CA1 region has stages: a short-term early potentiation lasting 1 to 3 hours, which is independent of protein synthesis, precedes a later, longer lasting stage (L-LTP), which requires protein synthesis. Inhibitors of cyclic adenosine monophosphate (cAMP) - dependent protein kinase (PKA) blocked L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L-LTP. The action of the cAMP analog was blocked by inhibitors of protein synthesis. Thus, activation of PKA may be a component of the mechanism that generates L-LTP.

Original languageEnglish (US)
Pages (from-to)1661-1664
Number of pages4
Issue number5114
StatePublished - 1993
Externally publishedYes

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