TY - JOUR
T1 - Effects of cyclosporin A on alveolar bone
T2 - An experimental study in the rat
AU - Fu, Earl
AU - Hsieh, Yao Dung
AU - Nieh, Shin
AU - Wikesjö, Ulf M E
AU - Liu, Demeral
PY - 1999/2
Y1 - 1999/2
N2 - Background: There have been several investigations on the role of cyclosporin A (CSA) in gingival hyperplasia in both animals and humans. However, less attention has been given to the drug's effect on alveolar bone. This study used light microscopy to histologically and histometrically evaluate the effects of CSA on alveolar bone in the rat. Methods: Sixty, 6- week-old Sprague-Dawley rats were separated into test and control groups. Animals in the test group received CSA in mineral oil (30 mg/kg body weight) daily by gastric feeding over the 6-week study. Control animals received only mineral oil. Ten animals from each group were sacrificed at weeks 2, 4, and 6. After histologic processing, the labial crest of the alveolar bone in the anterior mandible was evaluated by light microscopy. Results: A distinct pattern of increased osteoclasia and reduced bone formation was observed in the CSA-exposed animals compared to the controls. Increased osteoclasia was observed in periodontal sites and decreased bone formation was observed in symphyseal sites. Conclusions: The results suggest that CSA has distinct effects on alveolar bone.
AB - Background: There have been several investigations on the role of cyclosporin A (CSA) in gingival hyperplasia in both animals and humans. However, less attention has been given to the drug's effect on alveolar bone. This study used light microscopy to histologically and histometrically evaluate the effects of CSA on alveolar bone in the rat. Methods: Sixty, 6- week-old Sprague-Dawley rats were separated into test and control groups. Animals in the test group received CSA in mineral oil (30 mg/kg body weight) daily by gastric feeding over the 6-week study. Control animals received only mineral oil. Ten animals from each group were sacrificed at weeks 2, 4, and 6. After histologic processing, the labial crest of the alveolar bone in the anterior mandible was evaluated by light microscopy. Results: A distinct pattern of increased osteoclasia and reduced bone formation was observed in the CSA-exposed animals compared to the controls. Increased osteoclasia was observed in periodontal sites and decreased bone formation was observed in symphyseal sites. Conclusions: The results suggest that CSA has distinct effects on alveolar bone.
KW - Alveolar bone/anatomy and histology
KW - Animal studies; cyclosporin A/adverse effects; gingival hyperplasia
KW - Etiology
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U2 - 10.1902/jop.1999.70.2.189
DO - 10.1902/jop.1999.70.2.189
M3 - Article
C2 - 10102557
AN - SCOPUS:0033061888
SN - 0022-3492
VL - 70
SP - 189
EP - 194
JO - Journal of periodontology
JF - Journal of periodontology
IS - 2
ER -