Effects of cyclosporin A on the mandibular condylar cartilage in rats

S. Nieh; E. Fu; Y. D. Hsieh; U. M E Wikesjö; E. C. Shen

doi:10.1016/S0003-9969(99)00036-9

Effects of cyclosporin A on the mandibular condylar cartilage in rats

S. Nieh, E. Fu, Y. D. Hsieh, U. M E Wikesjö, E. C. Shen

Periodontics

Research output: Contribution to journal › Article › peer-review

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Abstract

Twenty, 5-week-old, male, Sprague-Dawley rats were divided into a control and a cyclosporin A (CSA) group for evaluating effects of the drug on condylar cartilage. Animals in the treatment group daily received CSA (15 mg/kg body wt) in mineral oil by gastric feeding over a 4-week observation interval. Control animals received mineral oil only. Five animals from each group were killed at weeks 2 and 4 of study. After histological processing, five tissue sections from the mid-region of the condyle were selected and examined. Three compositional zones (articular fibrous, proliferative, and hypertrophic) of the superior, posteriosuperior and posterior regions of the condylar cartilage were evaluated by light microscopy. At week 2, total condylar cartilage thickness was similar in the CSA and control groups, but the thickness of each zone was altered in CSA-treated animals, including a decrease of the fibrous and proliferative zones and an increase in hypertrophic zone compared to control (P < 0.05). At week 4, CSA-treated animals exhibited overall decreased cartilage thickness, including decreased thickness of each zone compared to control (P < 0.05). The results suggest that CSA has an inhibitory effect on the maturation of the mandibular condyle in rats.

Original language	English (US)
Pages (from-to)	693-700
Number of pages	8
Journal	Archives of Oral Biology
Volume	44
Issue number	8
DOIs	https://doi.org/10.1016/S0003-9969(99)00036-9
State	Published - May 1999

Keywords

Cartilage
Condyle
Cyclosporin
Histopathology

ASJC Scopus subject areas

Otorhinolaryngology
General Dentistry
Cell Biology

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10.1016/S0003-9969(99)00036-9

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title = "Effects of cyclosporin A on the mandibular condylar cartilage in rats",

abstract = "Twenty, 5-week-old, male, Sprague-Dawley rats were divided into a control and a cyclosporin A (CSA) group for evaluating effects of the drug on condylar cartilage. Animals in the treatment group daily received CSA (15 mg/kg body wt) in mineral oil by gastric feeding over a 4-week observation interval. Control animals received mineral oil only. Five animals from each group were killed at weeks 2 and 4 of study. After histological processing, five tissue sections from the mid-region of the condyle were selected and examined. Three compositional zones (articular fibrous, proliferative, and hypertrophic) of the superior, posteriosuperior and posterior regions of the condylar cartilage were evaluated by light microscopy. At week 2, total condylar cartilage thickness was similar in the CSA and control groups, but the thickness of each zone was altered in CSA-treated animals, including a decrease of the fibrous and proliferative zones and an increase in hypertrophic zone compared to control (P < 0.05). At week 4, CSA-treated animals exhibited overall decreased cartilage thickness, including decreased thickness of each zone compared to control (P < 0.05). The results suggest that CSA has an inhibitory effect on the maturation of the mandibular condyle in rats.",

keywords = "Cartilage, Condyle, Cyclosporin, Histopathology",

author = "S. Nieh and E. Fu and Hsieh, {Y. D.} and Wikesj{\"o}, {U. M E} and Shen, {E. C.}",

note = "Funding Information: Supported by the National Science Council, Republic of China, Grant No. NSC88-2314-B-016-103. We express gratitude to Mr Fu-Ckung Lieng for statistical support and to Ms Sheu Sheau Chyi, Paggy Tu and Cathy S.Y. Chen for histotechnical preparation.",

year = "1999",

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T1 - Effects of cyclosporin A on the mandibular condylar cartilage in rats

AU - Nieh, S.

AU - Fu, E.

AU - Hsieh, Y. D.

AU - Wikesjö, U. M E

AU - Shen, E. C.

N1 - Funding Information: Supported by the National Science Council, Republic of China, Grant No. NSC88-2314-B-016-103. We express gratitude to Mr Fu-Ckung Lieng for statistical support and to Ms Sheu Sheau Chyi, Paggy Tu and Cathy S.Y. Chen for histotechnical preparation.

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N2 - Twenty, 5-week-old, male, Sprague-Dawley rats were divided into a control and a cyclosporin A (CSA) group for evaluating effects of the drug on condylar cartilage. Animals in the treatment group daily received CSA (15 mg/kg body wt) in mineral oil by gastric feeding over a 4-week observation interval. Control animals received mineral oil only. Five animals from each group were killed at weeks 2 and 4 of study. After histological processing, five tissue sections from the mid-region of the condyle were selected and examined. Three compositional zones (articular fibrous, proliferative, and hypertrophic) of the superior, posteriosuperior and posterior regions of the condylar cartilage were evaluated by light microscopy. At week 2, total condylar cartilage thickness was similar in the CSA and control groups, but the thickness of each zone was altered in CSA-treated animals, including a decrease of the fibrous and proliferative zones and an increase in hypertrophic zone compared to control (P < 0.05). At week 4, CSA-treated animals exhibited overall decreased cartilage thickness, including decreased thickness of each zone compared to control (P < 0.05). The results suggest that CSA has an inhibitory effect on the maturation of the mandibular condyle in rats.

AB - Twenty, 5-week-old, male, Sprague-Dawley rats were divided into a control and a cyclosporin A (CSA) group for evaluating effects of the drug on condylar cartilage. Animals in the treatment group daily received CSA (15 mg/kg body wt) in mineral oil by gastric feeding over a 4-week observation interval. Control animals received mineral oil only. Five animals from each group were killed at weeks 2 and 4 of study. After histological processing, five tissue sections from the mid-region of the condyle were selected and examined. Three compositional zones (articular fibrous, proliferative, and hypertrophic) of the superior, posteriosuperior and posterior regions of the condylar cartilage were evaluated by light microscopy. At week 2, total condylar cartilage thickness was similar in the CSA and control groups, but the thickness of each zone was altered in CSA-treated animals, including a decrease of the fibrous and proliferative zones and an increase in hypertrophic zone compared to control (P < 0.05). At week 4, CSA-treated animals exhibited overall decreased cartilage thickness, including decreased thickness of each zone compared to control (P < 0.05). The results suggest that CSA has an inhibitory effect on the maturation of the mandibular condyle in rats.

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Effects of cyclosporin A on the mandibular condylar cartilage in rats

Abstract

Keywords

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