Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes

Ashley B. Jessup, Mary Beth Grimley, Echo Meyer, Gregory P. Passmore, Ayşenil Belger, William H. Hoffman, Ali S. Çalıkoğlu

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective: To evaluate the effects of diabetic ketoacidosis (DKA) on neurocognitive functions in children and adolescents presenting with newonset type 1 diabetes. Methods: Newly diagnosed patients were divided into two groups: those with DKA and those without DKA (non-DKA). Following metabolic stabilization, the patients took a mini-mental status exam prior to undergoing a baseline battery of cognitive tests that evaluated visual and verbal cognitive tasks. Follow-up testing was performed 8-12 weeks after diagnosis. Patients completed an IQ test at follow-up. Results: There was no statistical difference between the DKA and non-DKA groups neither in alertness at baseline testing nor in an IQ test at followup. The DKA group had significantly lower baseline scores than the non-DKA group for the visual cognitive tasks of design recognition, design memory and the composite visual memory index (VMI). At follow-up, Design Recognition remained statistically lower in the DKA group, but the design memory and the VMI tasks returned to statistical parity between the two groups. No significant differences were found in verbal cognitive tasks at baseline or follow-up between the two groups. Direct correlations were present for the admission CO2 and the visual cognitive tasks of VMI, design memory and design recognition. Direct correlations were also present for admission pH and VMI, design memory and picture memory. Conclusion: Pediatric patients presenting with newly diagnosed type 1 diabetes and severe but uncomplicated DKA showed a definite trend for lower cognitive functioning when compared to the age-matched patients without DKA.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalJCRPE Journal of Clinical Research in Pediatric Endocrinology
Issue number3
StatePublished - Sep 1 2015


  • Cognition
  • Dehydration
  • Diabetic ketoacidosis
  • Neuroinflammation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Effects of diabetic ketoacidosis on visual and verbal neurocognitive function in young patients presenting with new-onset type 1 diabetes'. Together they form a unique fingerprint.

Cite this