Effects of different growth factors and carriers on bone regeneration: A systematic review

Arash Khojasteh, Hossein Behnia, Navid Naghdi, Mohammad Esmaeelinejad, Zahra Alikhassy, Mark Stevens

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Objective: The application and subsequent investigations in the use of varied osteogenic growth factors in bone regeneration procedures have grown dramatically over the past several years. Owing to this rapid gain in popularity and documentation, a review was undertaken to evaluate the in vivo effects of growth factors on bone regeneration. Study Design: Using related key words, electronic databases (Medline, Embase, and Cochrane) were searched for articles published from 1999 to April 2010 to find growth factor application in bone regeneration in human or animal models. Results: A total of 63 articles were matched with the inclusion criteria of this study. Bone morphogenetic protein 2 (BMP-2) was the most studied growth factor. Carriers for the delivery, experimental sites, and methods of evaluation were different, and therefore articles did not come to a general agreement. Conclusions: Within the limitations of this review, BMP-2 may be an appropriate growth factor for osteogenesis.

Original languageEnglish (US)
Pages (from-to)e405-e423
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number6
StatePublished - Dec 2013

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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