Effects of diltiazem on anoxic injury in the isolated rat heart

Pacha Meyian Rahamathulla, Muhammad Ashraf, Arnold Schwartz, John Benedict

Research output: Contribution to journalArticlepeer-review


The effect of diltiazem, a calcium channel blocking agent, on anoxic injury was studied in isolated perfused rat hearts. Anoxia for 60 minutes caused a considerable release of creatine kinase and significant cell injury. Reoxygenation of these anoxic hearts for 20 minutes accelerated the creatine kinase release and caused severe cell injury. Reoxygenation of anoxic hearts with diltiazem at a rate of either 2 or 4.5 mg/liter did not reduce creatine kinase release significantly (probability [p] > 0.05). However, the higher dosage of diltiazem (4.5 mg/ liter during both anoxic and reoxygenation phases resulted in significant (p ≤ 0.05) preservation of healthy tissue. The data suggest that diltiazem in the higher concentration prevents cell injury and reduces mitochondrial damage in anoxic injury.

Original languageEnglish (US)
Pages (from-to)1081-1089
Number of pages9
JournalJournal of the American College of Cardiology
Issue number4
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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