Abstract
The biochemical mechanism underlying tremor is unknown. We investigated the effects of p-chlorophenylalanine (pCPA), a serotonin (5-HT) depletor, on the neurochemical processes in nuclei raphe dorsalis (NRD) and caudatus putamen (NCP) paralleling physostigmine-induced tremor in rats. Peak of physostigmine tremor correlated with increase in 5-HT in NRD and NCP, and a decrease in striatal dopamine (DA), as assayed employing high pressure liquid chromotography-electrochemistry. Administration of pCPA caused significant decrease in DA, norepinephrine (NE) and 5-HT levels in both the nuclei, without affecting striatal NE content and acetylcholinesterase activity. pCPA pretreatment significantly inhibited physostigmine-induced tremor and blocked corresponding increase in the levels of 5-HT in NRD and NCP. These results indicate involvement of central 5-HT, but not DA or NE, in the genesis of physostigmine tremor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-108 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 299 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 16 2001 |
| Externally published | Yes |
Keywords
- Dopamine
- Motor dysfunction
- Norepinephrine
- Serotonin (5-HT) mediation of tremor
ASJC Scopus subject areas
- General Neuroscience
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