TY - JOUR
T1 - Effects of progressive resistance training on immune response in aging and chronic inflammation
AU - Rall, Laura C.
AU - Roubenoff, Ronenn
AU - Cannon, Joseph G.
AU - Abad, Leslie W.
AU - Dinarello, Charles A.
AU - Meydani, Simin Nikbin
PY - 1996/11
Y1 - 1996/11
N2 - The effects of 12 wk of progressive resistance strength training on in vivo and in vitro immune parameters were evaluated in a controlled study of eight subjects with rheumatoid arthritis (RA), eight healthy young (22-30 yr), and eight healthy elderly (65-80 yr) individuals. Six healthy elderly (65-80 yr) nontraining control subjects were also evaluated to account for seasonal and psychosocial effects. Training subjects exercised at 80% of their one-repetition maximum and performed eight repetitions per set, three sets per session on a twice weekly basis. Peripheral blood mononuclear cell (PBMC) subpopulations, cytokine and prostaglandin (PG) E2 production, proliferative response, and delayed type hypersensitivity (DTH) skin response were measured before and after 12 wk of training. Training did not induce changes in PBMC subsets, interleukin (IL)-1 β, tumor necrosis factor-α (TNF), IL-6, IL-2, or PGE2 production, lymphocyte proliferation, or DTH response in any of the training groups compared with control subjects. These data suggest that 12 wk of high-intensity progressive resistance strength training does not affect immune function in young or elderly healthy individuals or subjects with RA.
AB - The effects of 12 wk of progressive resistance strength training on in vivo and in vitro immune parameters were evaluated in a controlled study of eight subjects with rheumatoid arthritis (RA), eight healthy young (22-30 yr), and eight healthy elderly (65-80 yr) individuals. Six healthy elderly (65-80 yr) nontraining control subjects were also evaluated to account for seasonal and psychosocial effects. Training subjects exercised at 80% of their one-repetition maximum and performed eight repetitions per set, three sets per session on a twice weekly basis. Peripheral blood mononuclear cell (PBMC) subpopulations, cytokine and prostaglandin (PG) E2 production, proliferative response, and delayed type hypersensitivity (DTH) skin response were measured before and after 12 wk of training. Training did not induce changes in PBMC subsets, interleukin (IL)-1 β, tumor necrosis factor-α (TNF), IL-6, IL-2, or PGE2 production, lymphocyte proliferation, or DTH response in any of the training groups compared with control subjects. These data suggest that 12 wk of high-intensity progressive resistance strength training does not affect immune function in young or elderly healthy individuals or subjects with RA.
KW - CYTOKINES
KW - EXERCISE
KW - INFLAMMATION
KW - LYMPHOCYTES
UR - http://www.scopus.com/inward/record.url?scp=0029963658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029963658&partnerID=8YFLogxK
U2 - 10.1097/00005768-199611000-00003
DO - 10.1097/00005768-199611000-00003
M3 - Article
C2 - 8933485
AN - SCOPUS:0029963658
SN - 0195-9131
VL - 28
SP - 1356
EP - 1365
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
IS - 11
ER -