Abstract
Female obese Zucker rats (aged 6 wk) were randomly assigned to one of two control or one of three experimental-diet groups. Experimental diets contained 6% pyruvate (Pyr), 6% dihydroxyacetone (Dha), or 3% each pyruvate and dihydroxyacetone (Pyr-Dha). Control-group 1 was fed a normal diet ad libitum and control-group 2 was pair fed according to the experimental group with the lowest consumption. After 5 wk the rats receiving Pyr (357.5 ± 12.7 g) were significantly lighter than pair-fed (385.9 ± 4.9 g) and ad libitum-fed (404.3 ± 10.1) controls. Resting oxygen consumption (mL·min-1·kg0.65) was significantly higher in Pyr-fed rats than in pair-fed controls and food-conversion efficiency was significantly decreased. Rats fed Pyr had a lower resting respiratory-exchange ratio than did ad libitum- and pair-fed controls (0.81 ± 0.01 vs 0.88 ± 0.01 and 0.87 ± 0.01, respectively). Results suggest that pyruvate consumption reduced the weight gain and food-conversion efficiency of obese Zucker rats, in part by increasing resting metabolic rate and fatty acid oxidation.
Original language | English (US) |
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Pages (from-to) | 847-853 |
Number of pages | 7 |
Journal | American Journal of Clinical Nutrition |
Volume | 53 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1991 |
Externally published | Yes |
Keywords
- Dihydroxyacetone
- Hepatic steatosis
- Oxygen consumption
- Pyruvate
- Resting metabolic rate
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics