Effects of regular and low-fluoride dentifrices on plaque fluoride

J. P. Pessan, K. M.R.P. Alves, I. Ramires, M. F.L. Taga, F. C. Sampaio, G. M. Whitford, M. A.R. Buzalaf

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22 Scopus citations


Previous studies have indicated that the use of low-fluoride dentifrices could lead to proportionally higher plaque fluoride levels when compared with conventional dentifrices. This double-blind, randomized, crossover study determined the effects of placebo, low-fluoride, and conventional dentifrices on plaque fluoride concentrations ([F]) in children living in communities with 0.04, 0.72, and 3.36 ppm F in the drinking water. Children used the toothpastes twice daily, for 1 wk. Samples were collected 1 and 12 hrs after the last use of dentifrices and were analyzed for fluoride and calcium. Similar increases were found 1 hr after the children brushed with low-fluoride (ca. 1.9 mmol F/kg) and conventional (ca. 2.4 mmol F/kg) dentifrices in the 0.04- and 0.72-ppm-F communities. Despite the fact that the increases were less pronounced in the 3.36-ppm-F community, our results indicate that the use of a low-fluoride dentifrice promotes a proportionally higher increase in plaque [F] when compared with that achieved with a conventional dentifrice, based on dose-response considerations.

Original languageEnglish (US)
Pages (from-to)1106-1110
Number of pages5
JournalJournal of Dental Research
Issue number10
StatePublished - Oct 2010


  • calcium
  • dental plaque
  • fluoride
  • fluoride dentifrice

ASJC Scopus subject areas

  • Dentistry(all)


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