Effects of scopolamine on visual evoked potentials in aging and dementia

P. G. Ray; K. J. Meador; D. W. Loring; A. M. Murro; J. J. Buccafusco; X. H. Yang; E. Y. Zamrini; W. O. Thompson; E. E. Thompson

doi:10.1016/0168-5597(91)90081-8

Effects of scopolamine on visual evoked potentials in aging and dementia

P. G. Ray, K. J. Meador, D. W. Loring, A. M. Murro, J. J. Buccafusco, X. H. Yang, E. Y. Zamrini, W. O. Thompson, E. E. Thompson

Neurology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Falsh P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.

Original language	English (US)
Pages (from-to)	347-351
Number of pages	5
Journal	Electroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/0168-5597(91)90081-8
State	Published - 1991

Keywords

Aging
Cholinergic blockade
Dementia
Scopolamine
Visual evoked potential

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/0168-5597(91)90081-8

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title = "Effects of scopolamine on visual evoked potentials in aging and dementia",

abstract = "The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Falsh P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.",

keywords = "Aging, Cholinergic blockade, Dementia, Scopolamine, Visual evoked potential",

author = "Ray, {P. G.} and Meador, {K. J.} and Loring, {D. W.} and Murro, {A. M.} and Buccafusco, {J. J.} and Yang, {X. H.} and Zamrini, {E. Y.} and Thompson, {W. O.} and Thompson, {E. E.}",

note = "Funding Information: The authors wish to thank O. Abney for technical assistance. The investigators were supported by NIA/NIH grant No. K08 AG00314 and by the Medical College of Georgia Research Institute. The paper was presented in part at the 1990 annual meeting of the International Neuropsychological Society, Kissimmee, FL.",

year = "1991",

doi = "10.1016/0168-5597(91)90081-8",

language = "English (US)",

volume = "80",

pages = "347--351",

journal = "Electroencephalography and Clinical Neurophysiology/ Evoked Potentials",

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AU - Ray, P. G.

AU - Meador, K. J.

AU - Loring, D. W.

AU - Murro, A. M.

AU - Buccafusco, J. J.

AU - Yang, X. H.

AU - Zamrini, E. Y.

AU - Thompson, W. O.

AU - Thompson, E. E.

N1 - Funding Information: The authors wish to thank O. Abney for technical assistance. The investigators were supported by NIA/NIH grant No. K08 AG00314 and by the Medical College of Georgia Research Institute. The paper was presented in part at the 1990 annual meeting of the International Neuropsychological Society, Kissimmee, FL.

PY - 1991

Y1 - 1991

N2 - The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Falsh P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.

AB - The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Falsh P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.

KW - Aging

KW - Cholinergic blockade

KW - Dementia

KW - Scopolamine

KW - Visual evoked potential

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Effects of scopolamine on visual evoked potentials in aging and dementia

Abstract

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