Effects of sodium pentothal and sufentanil on serotonin induced constriction of canine coronary artery rings without endothelium

R. P.S. Introna; J. K. Pruett; Dan C Martin; D. Josephson; M. Manabe

doi:10.1016/0306-3623(91)90061-A

Effects of sodium pentothal and sufentanil on serotonin induced constriction of canine coronary artery rings without endothelium

R. P.S. Introna, J. K. Pruett, Dan C Martin, D. Josephson, M. Manabe

Anesthesiology and Perioperative Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

1. 1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26 μM are reached. 3. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.

Original language	English (US)
Pages (from-to)	589-594
Number of pages	6
Journal	General Pharmacology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/0306-3623(91)90061-A
State	Published - Jan 1 1991

ASJC Scopus subject areas

Pharmacology

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10.1016/0306-3623(91)90061-A

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title = "Effects of sodium pentothal and sufentanil on serotonin induced constriction of canine coronary artery rings without endothelium",

abstract = "1. 1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26 μM are reached. 3. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.",

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AU - Introna, R. P.S.

AU - Pruett, J. K.

AU - Martin, Dan C

AU - Josephson, D.

AU - Manabe, M.

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N2 - 1. 1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26 μM are reached. 3. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.

AB - 1. 1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26 μM are reached. 3. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.

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Effects of sodium pentothal and sufentanil on serotonin induced constriction of canine coronary artery rings without endothelium

Abstract

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