Effects of the water soluble fraction from leaves of Ageratum conyzoides on smooth muscle

Maria Jeane Margort E. Silva; Francisco Ruy Capaz; Marcus Raimundo Vale

doi:10.1002/(SICI)1099-1573(200003)14:2<130::AID-PTR594>3.0.CO;2-4

Effects of the water soluble fraction from leaves of Ageratum conyzoides on smooth muscle

Maria Jeane Margort E. Silva, Francisco Ruy Capaz, Marcus Raimundo Vale

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The water soluble fraction of Ageratum conyzoides L. (WSF) was studied in isolated rat uterus and intestinal smooth muscles in order to evaluate its popular use as a spasmolytic. WSF (0.2 and 0.4 mg/mL) increased EC₅₀ values and decreased maximum responses to acetylcholine and calcium chloride. WSF (0.5-3.3 mg/mL) also produced direct myorelaxant effect on smooth muscle preparations. Theophylline (10^-3 M) potentiated the relaxant action of WSF. Theophylline also prevented the decrease in maximum response promoted by WSF in acetylcholine concentration-effect curves. These results seem to be partially linked to calcium mobilization. The data also suggest that WSF could act synergistically with theophylline in the inhibition of cyclic AMP phosphodiesterase. The results give support to the popular medicinal indications of the plant. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original language	English (US)
Pages (from-to)	130-132
Number of pages	3
Journal	Phytotherapy Research
Volume	14
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1099-1573(200003)14:2<130::AID-PTR594>3.0.CO;2-4
State	Published - Mar 2000
Externally published	Yes

Keywords

Ageratum conyzoides
Myorelaxant effect
Phosphodiesterase
Smooth muscle

ASJC Scopus subject areas

Pharmacology

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10.1002/(SICI)1099-1573(200003)14:2<130::AID-PTR594>3.0.CO;2-4

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title = "Effects of the water soluble fraction from leaves of Ageratum conyzoides on smooth muscle",

abstract = "The water soluble fraction of Ageratum conyzoides L. (WSF) was studied in isolated rat uterus and intestinal smooth muscles in order to evaluate its popular use as a spasmolytic. WSF (0.2 and 0.4 mg/mL) increased EC50 values and decreased maximum responses to acetylcholine and calcium chloride. WSF (0.5-3.3 mg/mL) also produced direct myorelaxant effect on smooth muscle preparations. Theophylline (10-3 M) potentiated the relaxant action of WSF. Theophylline also prevented the decrease in maximum response promoted by WSF in acetylcholine concentration-effect curves. These results seem to be partially linked to calcium mobilization. The data also suggest that WSF could act synergistically with theophylline in the inhibition of cyclic AMP phosphodiesterase. The results give support to the popular medicinal indications of the plant. Copyright (C) 2000 John Wiley and Sons, Ltd.",

keywords = "Ageratum conyzoides, Myorelaxant effect, Phosphodiesterase, Smooth muscle",

author = "Silva, {Maria Jeane Margort E.} and Capaz, {Francisco Ruy} and Vale, {Marcus Raimundo}",

year = "2000",

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AU - Capaz, Francisco Ruy

AU - Vale, Marcus Raimundo

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Y1 - 2000/3

N2 - The water soluble fraction of Ageratum conyzoides L. (WSF) was studied in isolated rat uterus and intestinal smooth muscles in order to evaluate its popular use as a spasmolytic. WSF (0.2 and 0.4 mg/mL) increased EC50 values and decreased maximum responses to acetylcholine and calcium chloride. WSF (0.5-3.3 mg/mL) also produced direct myorelaxant effect on smooth muscle preparations. Theophylline (10-3 M) potentiated the relaxant action of WSF. Theophylline also prevented the decrease in maximum response promoted by WSF in acetylcholine concentration-effect curves. These results seem to be partially linked to calcium mobilization. The data also suggest that WSF could act synergistically with theophylline in the inhibition of cyclic AMP phosphodiesterase. The results give support to the popular medicinal indications of the plant. Copyright (C) 2000 John Wiley and Sons, Ltd.

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Effects of the water soluble fraction from leaves of Ageratum conyzoides on smooth muscle

Abstract

Keywords

ASJC Scopus subject areas

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