Abstract
The efficacy of voriconazole in combination with amphotericin B or micafungin was studied in a transiently neutropenic guinea-pig model of invasive pulmonary aspergillosis. Guinea-pigs treated with the antifungal drugs, alone or in two-drug combinations, had an improved survival rate and reduced fungal burden in the lungs compared to untreated control animals. The efficacy of monotherapy and combination therapy was similar; activity was neither enhanced nor reduced with the two-drug combinations. Further studies of efficacy, dosing and optimal regimens for antifungal combinations are warranted.
Original language | English (US) |
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Pages (from-to) | 925-928 |
Number of pages | 4 |
Journal | Clinical Microbiology and Infection |
Volume | 10 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2004 |
Externally published | Yes |
Keywords
- Amphotericin B
- Aspergillosis
- Guinea-pig model
- Micafungin
- Pulmonary aspergillosis
- Voriconazole
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases