Emerging role of autophagy in kidney function, diseases and aging

Tobias B. Huber, Charles L. Edelstein, Björn Hartleben, Ken Inoki, Man Jiang, Daisuke Koya, Shinji Kume, Wilfred Lieberthal, Nicolas Pallet, Alejandro Quiroga, Kameswaran Ravichandran, Katalin Susztak, Sei Yoshida, Zheng Dong

Research output: Contribution to journalReview articlepeer-review

214 Scopus citations


Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.

Original languageEnglish (US)
Pages (from-to)1009-1031
Number of pages23
Issue number7
StatePublished - Jul 2012


  • Acute kidney injury
  • Aging
  • Autophagy
  • Glomerulus
  • Kidney
  • Kidney transplantation
  • Podocyte
  • Polycystic kidney disease
  • mTOR

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Emerging role of autophagy in kidney function, diseases and aging'. Together they form a unique fingerprint.

Cite this