@article{0a0f99fd0d6f42f5afe7228bef4cdcf4,
title = "Emerging roles of ALK in immunity and insights for immunotherapy",
abstract = "Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers.",
keywords = "ALK-related immunotherapies, ALK-wildtype and aberrations in immunity",
author = "Lan Wang and Lui, {Vivian Wai Yan}",
note = "Funding Information: This is funded by the General Research Fund (#17121616 to VWYL, Research Grant Council, Hong Kong Government, Hong Kong SAR). V.W.Y.L. also receives fundings from the Research Grant Council, General Research Fund—17114814, 17121616, 14168517, and R4017-18; Research Impact Fund; the Health and Medical Research Fund (HMRF#15160691, the Health and Medical Research Fund, the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region); University-Industry Collaboration Program (UIM/329; Innovation and Technology Fund, Hong Kong government, Hong Kong SAR and Lee{\textquoteright}s Pharmaceutical (HK) Limited); the Hong Kong Cancer Fund, Hong Kong SAR; Start-up Fund from the School of Biomedical Sciences, Faculty of Medicine, CUHK. Acknowledgments: This is funded by General Research Fund #17121616, Research Grant Council, Hong Kong Government, Hong Kong SAR. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = feb,
doi = "10.3390/cancers12020426",
language = "English (US)",
volume = "12",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}
