Emerging roles of ATF3 in the suppression of prostate cancer

Ziyan Wang; Chunhong Yan

doi:10.1080/23723556.2015.1010948

Emerging roles of ATF3 in the suppression of prostate cancer

Ziyan Wang, Chunhong Yan

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.

Original language	English (US)
Article number	e1010948
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1010948
State	Published - Jan 2 2016

Keywords

ATF3
PTEN
akt
prostate cancer

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1010948

Cite this

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abstract = "Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.",

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Emerging roles of ATF3 in the suppression of prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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