Abstract
Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.
| Original language | English (US) |
|---|---|
| Article number | e1010948 |
| Journal | Molecular and Cellular Oncology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- ATF3
- PTEN
- akt
- prostate cancer
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research
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