Endocrine-autonomic linkages

Celia D. Sladek, Lisete C. Michelini, Nina S. Stachenfeld, Javier E. Stern, Janice H. Urban

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Interaction between the autonomic nervous system and the neuroendocrine system is critical for maintenance of homeostasis in a wide variety of physiological parameters such as body temperature, fluid and electrolyte balance, and blood pressure and volume. The anatomical and physiological mechanisms underlying integration of the neuroendocrine and autonomic mechanisms responsible for eliciting integrated autonomic and neuroendocrine actions are the focus of this article. This includes a focus on the hypothalamic paraventricular nucleus, because it includes both neuroendocrine neurons and preganglionic autonomic neurons that regulate sympathetic and parasympathetic outflow. The "wired" and "nonwired" mechanisms within PVN that facilitate communication between these neuronal populations are described. The impact of peripheral hormones, specifically the adrenal and gonadal steroids, on the neuroendocrine and autonomic systems is discussed, and exercise is used as a specific example of a physiological challenge/stress that requires precise integration of neuroendocrine and autonomic responses to maintain cardiovascular, fluid, and energy homeostasis.

Original languageEnglish (US)
Pages (from-to)1281-1323
Number of pages43
JournalComprehensive Physiology
Issue number3
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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