Endogenous pyrogen activity in human plasma after exercise

Joseph G. Cannon, Matthew J. Kluger

Research output: Contribution to journalArticlepeer-review

194 Scopus citations


Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.

Original languageEnglish (US)
Pages (from-to)617-619
Number of pages3
Issue number4597
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Endogenous pyrogen activity in human plasma after exercise'. Together they form a unique fingerprint.

Cite this