Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonist

Laura Detti; Frank D. Yelian; Michael L. Kruger; Michael P. Diamond; Anuradha Rode; Mohamed F.M. Mitwally; Elizabeth E. Puscheck

doi:10.1016/j.fertnstert.2007.04.027

Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonist

Laura Detti, Frank D. Yelian, Michael L. Kruger, Michael P. Diamond, Anuradha Rode, Mohamed F.M. Mitwally, Elizabeth E. Puscheck

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

In this retrospective cohort study of 102 ovarian stimulation cycles for IVF/intracytoplasmic sperm injection using GnRH antagonist and gonadotropins, we sought to assess the effect of high E₂ levels on endometrial stripe thickness and its association with pregnancy outcomes and serum E₂ levels. We found no significant correlation between serum E₂ levels (both peak and area under the curve E₂ concentration) and the endometrial thickness. However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%).

Original language	English (US)
Pages (from-to)	998-1001
Number of pages	4
Journal	Fertility and sterility
Volume	89
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2007.04.027
State	Published - Apr 2008
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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Detti, L., Yelian, F. D., Kruger, M. L., Diamond, M. P., Rode, A., Mitwally, M. F. M., & Puscheck, E. E. (2008). Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonist. Fertility and sterility, 89(4), 998-1001. https://doi.org/10.1016/j.fertnstert.2007.04.027

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abstract = "In this retrospective cohort study of 102 ovarian stimulation cycles for IVF/intracytoplasmic sperm injection using GnRH antagonist and gonadotropins, we sought to assess the effect of high E2 levels on endometrial stripe thickness and its association with pregnancy outcomes and serum E2 levels. We found no significant correlation between serum E2 levels (both peak and area under the curve E2 concentration) and the endometrial thickness. However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%).",

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AU - Yelian, Frank D.

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AU - Diamond, Michael P.

AU - Rode, Anuradha

AU - Mitwally, Mohamed F.M.

AU - Puscheck, Elizabeth E.

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AB - In this retrospective cohort study of 102 ovarian stimulation cycles for IVF/intracytoplasmic sperm injection using GnRH antagonist and gonadotropins, we sought to assess the effect of high E2 levels on endometrial stripe thickness and its association with pregnancy outcomes and serum E2 levels. We found no significant correlation between serum E2 levels (both peak and area under the curve E2 concentration) and the endometrial thickness. However, there was a statistically significant inverse relationship with early pregnancy loss (31%) if the endometrial thickness was <9.8 mm (sensitivity 71%; specificity 76%).

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Endometrial thickness is related to miscarriage rate, but not to the estradiol concentration, in cycles down-regulated with gonadotropin-releasing hormone antagonist

Abstract

ASJC Scopus subject areas

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