Endoscopic endonasal CSF rhinorrhea repair in children: Systematic review with meta-analysis

Chadi A. Makary, Habib G. Zalzal, Jad Ramadan, Hassan H. Ramadan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: Cerebrospinal fluid (CSF) rhinorrhea in children is relatively uncommon. Endoscopic repair techniques in adults have become first line for nasal-based CSF leaks, and this meta-analysis looks at the success rates of CSF leak cessation following endoscopic repair in children. Methods: Three researchers extracted information involving patient population, surgical technique, outcomes of interest, and study design. A computerized search of MEDLINE, EMBASE and the Cochrane library (January 1990–September 2019) looked for several papers on the subject of CSF leak repair in children using endoscopic technique. Results: A total of 15 studies met inclusion criteria. Endoscopic repair of CSF rhinorrhea in children shows a pooled weighted success rate of 94% after first attempt. The most common etiology was traumatic followed by congenital. Iatrogenic defects secondary to tumor resection are becoming more common. The high success rate was irrespective of the techniques using. Conclusion: Endoscopic repair techniques have a highly successful closure rate for children presenting with CSF rhinorrhea.

Original languageEnglish (US)
Article number110044
JournalInternational Journal of Pediatric Otorhinolaryngology
StatePublished - Jul 2020
Externally publishedYes


  • CSF
  • CSF leak
  • CSF leak Repair
  • Cerebrospinal fluid
  • Endoscopic sinus surgery
  • Rhinorrhea

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology


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