Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

Christoph Wiesner; Jiri Kopecky; Maren Pflueger; Harald Hundsberger; Barbara Entler; Christoph Kleber; Josef Atzler; Pavel Hrouzek; Dalibor Stys; Alena Lukesova; Wolfgang Schuett; Rudolf Lucas

doi:10.2174/187231207783221385

Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

Christoph Wiesner, Jiri Kopecky, Maren Pflueger, Harald Hundsberger, Barbara Entler, Christoph Kleber, Josef Atzler, Pavel Hrouzek, Dalibor Stys, Alena Lukesova, Wolfgang Schuett, Rudolf Lucas

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Original language	English (US)
Pages (from-to)	254-260
Number of pages	7
Journal	Drug Metabolism Letters
Volume	1
Issue number	4
DOIs	https://doi.org/10.2174/187231207783221385
State	Published - Dec 2007

ASJC Scopus subject areas

Pharmaceutical Science
Clinical Biochemistry
Biochemistry, medical
Pharmacology (medical)

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Wiesner, C., Kopecky, J., Pflueger, M., Hundsberger, H., Entler, B., Kleber, C., Atzler, J., Hrouzek, P., Stys, D., Lukesova, A., Schuett, W., & Lucas, R. (2007). Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites. Drug Metabolism Letters, 1(4), 254-260. https://doi.org/10.2174/187231207783221385

Wiesner, C, Kopecky, J, Pflueger, M, Hundsberger, H, Entler, B, Kleber, C, Atzler, J, Hrouzek, P, Stys, D, Lukesova, A, Schuett, W & Lucas, R 2007, 'Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.', Drug Metabolism Letters, vol. 1, no. 4, pp. 254-260. https://doi.org/10.2174/187231207783221385

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abstract = "Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.",

author = "Christoph Wiesner and Jiri Kopecky and Maren Pflueger and Harald Hundsberger and Barbara Entler and Christoph Kleber and Josef Atzler and Pavel Hrouzek and Dalibor Stys and Alena Lukesova and Wolfgang Schuett and Rudolf Lucas",

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AU - Wiesner, Christoph

AU - Kopecky, Jiri

AU - Pflueger, Maren

AU - Hundsberger, Harald

AU - Entler, Barbara

AU - Kleber, Christoph

AU - Atzler, Josef

AU - Hrouzek, Pavel

AU - Stys, Dalibor

AU - Lukesova, Alena

AU - Schuett, Wolfgang

AU - Lucas, Rudolf

PY - 2007/12

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AB - Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

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Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

Abstract

ASJC Scopus subject areas

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