Abstract
We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ET A or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.
Original language | English (US) |
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Pages (from-to) | 1219-1227 |
Number of pages | 9 |
Journal | Peptides |
Volume | 26 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2005 |
Externally published | Yes |
Keywords
- Bile flow
- ET receptors
- ET receptors
- ET-3
- Nitric oxide
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience