Endothelin and diabetic complications: A brain-centric view

W. Li, Y. Abdul, R. Ward, A. Ergul

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and quality of life. Small vessel disease in the cerebral vasculature plays a major role in the pathogenesis of cognitive impairment in diabetes. Endothelin system, including endothelin-1 (ET-1) and the receptors (ETA and ETB), is a likely candidate that may be involved in many aspects of the diabetes cerebrovascular disease. In this review, we took a brain-centric approach and discussed the role of the ET system in cerebrovascular and cognitive dysfunction in diabetes.

Original languageEnglish (US)
Pages (from-to)S83-S94
JournalPhysiological Research
StatePublished - 2018


  • Cerebrovascular dysfunction
  • Cognitive impairment
  • Diabetes
  • Endothelin
  • Neurovascular unit

ASJC Scopus subject areas

  • Physiology


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