Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

Hai Long Ruan; Xiang Li; Hong Mei Yang; Zheng Shuai Song; Jun Wei Tong; Qi Cao; Ke Shan Wang; Wen Xiao; Hai Bin Xiao; Xuan Yu Chen; Guang Hua Xu; Lin Bao; Zhi Yong Xiong; Chang Fei Yuan; Lei Liu; Yan Qu; Wen Jun Hu; Yao Ying Gao; Ze Yuan Ru; Ke Chen; Xiao Ping Zhang

doi:10.1016/j.yexcr.2017.07.004

Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

Hai Long Ruan, Xiang Li, Hong Mei Yang, Zheng Shuai Song, Jun Wei Tong, Qi Cao, Ke Shan Wang, Wen Xiao, Hai Bin Xiao, Xuan Yu Chen, Guang Hua Xu, Lin Bao, Zhi Yong Xiong, Chang Fei Yuan, Lei Liu, Yan Qu, Wen Jun Hu, Yao Ying Gao, Ze Yuan Ru, Ke ChenXiao Ping Zhang

Neuroscience and Regenerative Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and was significantly associated with various clinicopathological parameters. In addition, high CAV1 expression was associated with poor disease-free survival (DFS) rate and could serve as a useful diagnostic indicator in ccRCC patients with different clinicopathological stages. Functional experiments demonstrated that CAV1 knockdown inhibited cell migration and invasion, whereas overexpression of CAV1 promoted cell migration and invasion in ccRCC. Moreover, CAV1 expression was up-regulated in sunitinib-resistant renal cancer cell lines, and its overexpression promoted sunitinib resistance. In general, our results confirm that CAV1 plays an important role in the metastasis of kidney cancer and induces sunitinib resistance, so CAV1 function suppression may become a promising clinical treatment strategy during renal cell carcinoma metastasis and sunitinib resistance.

Original language	English (US)
Pages (from-to)	269-278
Number of pages	10
Journal	Experimental Cell Research
Volume	358
Issue number	2
DOIs	https://doi.org/10.1016/j.yexcr.2017.07.004
State	Published - Sep 15 2017

Keywords

CAV1
Diagnosis
Invasion
Prognosis
Sunitinib-resistance
ccRCC

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.yexcr.2017.07.004

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Ruan, H. L., Li, X., Yang, H. M., Song, Z. S., Tong, J. W., Cao, Q., Wang, K. S., Xiao, W., Xiao, H. B., Chen, X. Y., Xu, G. H., Bao, L., Xiong, Z. Y., Yuan, C. F., Liu, L., Qu, Y., Hu, W. J., Gao, Y. Y., Ru, Z. Y., ... Zhang, X. P. (2017). Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma. Experimental Cell Research, 358(2), 269-278. https://doi.org/10.1016/j.yexcr.2017.07.004

Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma. / Ruan, Hai Long; Li, Xiang; Yang, Hong Mei et al.
In: Experimental Cell Research, Vol. 358, No. 2, 15.09.2017, p. 269-278.

Research output: Contribution to journal › Article › peer-review

Ruan, HL, Li, X, Yang, HM, Song, ZS, Tong, JW, Cao, Q, Wang, KS, Xiao, W, Xiao, HB, Chen, XY, Xu, GH, Bao, L, Xiong, ZY, Yuan, CF, Liu, L, Qu, Y, Hu, WJ, Gao, YY, Ru, ZY, Chen, K & Zhang, XP 2017, 'Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma', Experimental Cell Research, vol. 358, no. 2, pp. 269-278. https://doi.org/10.1016/j.yexcr.2017.07.004

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title = "Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma",

abstract = "Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and was significantly associated with various clinicopathological parameters. In addition, high CAV1 expression was associated with poor disease-free survival (DFS) rate and could serve as a useful diagnostic indicator in ccRCC patients with different clinicopathological stages. Functional experiments demonstrated that CAV1 knockdown inhibited cell migration and invasion, whereas overexpression of CAV1 promoted cell migration and invasion in ccRCC. Moreover, CAV1 expression was up-regulated in sunitinib-resistant renal cancer cell lines, and its overexpression promoted sunitinib resistance. In general, our results confirm that CAV1 plays an important role in the metastasis of kidney cancer and induces sunitinib resistance, so CAV1 function suppression may become a promising clinical treatment strategy during renal cell carcinoma metastasis and sunitinib resistance.",

keywords = "CAV1, Diagnosis, Invasion, Prognosis, Sunitinib-resistance, ccRCC",

author = "Ruan, {Hai Long} and Xiang Li and Yang, {Hong Mei} and Song, {Zheng Shuai} and Tong, {Jun Wei} and Qi Cao and Wang, {Ke Shan} and Wen Xiao and Xiao, {Hai Bin} and Chen, {Xuan Yu} and Xu, {Guang Hua} and Lin Bao and Xiong, {Zhi Yong} and Yuan, {Chang Fei} and Lei Liu and Yan Qu and Hu, {Wen Jun} and Gao, {Yao Ying} and Ru, {Ze Yuan} and Ke Chen and Zhang, {Xiao Ping}",

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T1 - Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

AU - Ruan, Hai Long

AU - Li, Xiang

AU - Yang, Hong Mei

AU - Song, Zheng Shuai

AU - Tong, Jun Wei

AU - Cao, Qi

AU - Wang, Ke Shan

AU - Xiao, Wen

AU - Xiao, Hai Bin

AU - Chen, Xuan Yu

AU - Xu, Guang Hua

AU - Bao, Lin

AU - Xiong, Zhi Yong

AU - Yuan, Chang Fei

AU - Liu, Lei

AU - Qu, Yan

AU - Hu, Wen Jun

AU - Gao, Yao Ying

AU - Ru, Ze Yuan

AU - Chen, Ke

AU - Zhang, Xiao Ping

PY - 2017/9/15

Y1 - 2017/9/15

N2 - Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and was significantly associated with various clinicopathological parameters. In addition, high CAV1 expression was associated with poor disease-free survival (DFS) rate and could serve as a useful diagnostic indicator in ccRCC patients with different clinicopathological stages. Functional experiments demonstrated that CAV1 knockdown inhibited cell migration and invasion, whereas overexpression of CAV1 promoted cell migration and invasion in ccRCC. Moreover, CAV1 expression was up-regulated in sunitinib-resistant renal cancer cell lines, and its overexpression promoted sunitinib resistance. In general, our results confirm that CAV1 plays an important role in the metastasis of kidney cancer and induces sunitinib resistance, so CAV1 function suppression may become a promising clinical treatment strategy during renal cell carcinoma metastasis and sunitinib resistance.

AB - Caveolin-1 (CAV1) has been identified to be up-regulated in many cancers, including clear cell renal cell carcinoma (ccRCC). However, its potential function is still unclear in ccRCC. In this study, we demonstrated that CAV1 was frequently overexpressed in renal cell carcinoma tissues and cells, and was significantly associated with various clinicopathological parameters. In addition, high CAV1 expression was associated with poor disease-free survival (DFS) rate and could serve as a useful diagnostic indicator in ccRCC patients with different clinicopathological stages. Functional experiments demonstrated that CAV1 knockdown inhibited cell migration and invasion, whereas overexpression of CAV1 promoted cell migration and invasion in ccRCC. Moreover, CAV1 expression was up-regulated in sunitinib-resistant renal cancer cell lines, and its overexpression promoted sunitinib resistance. In general, our results confirm that CAV1 plays an important role in the metastasis of kidney cancer and induces sunitinib resistance, so CAV1 function suppression may become a promising clinical treatment strategy during renal cell carcinoma metastasis and sunitinib resistance.

KW - CAV1

KW - Diagnosis

KW - Invasion

KW - Prognosis

KW - Sunitinib-resistance

KW - ccRCC

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Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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