Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice

Suzhen Dong, Chunxia Li, Pu Wu, Joe Z. Tsien, Yinghe Hu

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Presenilin (PS) 1 and 2 conditional double knockout (cDKO) mice show progressive memory dysfunction and forebrain degeneration. Gene expression profiling results revealed a strong activation of immunity and inflammation responses in the brains of 10-month-old cDKO mice. As environmental enrichment (EE) has been shown to be able to improve memory and induce neurogenesis of the brain, we assessed the effects of EE on the memory performance and the neurodegeneration in cDKO mice. We found that EE effectively enhanced memory and partially rescued the forebrain atrophy of the cDKO mice. Our results suggest that immunity and inflammation could play important roles in the neurodegeneration of cDKO mice. Furthermore, the beneficial effects of EE may be associated with the inhibition of the expression of immunity and inflammation-related genes in the brain.

Original languageEnglish (US)
Pages (from-to)101-112
Number of pages12
JournalEuropean Journal of Neuroscience
Issue number1
StatePublished - Jul 2007
Externally publishedYes


  • Forebrain degeneration
  • Immunity
  • Inflammation
  • Memory performance
  • Neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)


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