TY - JOUR
T1 - EORTC/MSGERC Definitions of Invasive Fungal Diseases
T2 - Summary of Activities of the Intensive Care Unit Working Group
AU - Bassetti, Matteo
AU - Azoulay, Elie
AU - Kullberg, Bart Jan
AU - Ruhnke, Markus
AU - Shoham, Shmuel
AU - Vazquez, Jose
AU - Giacobbe, Daniele Roberto
AU - Calandra, Thierry
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2021/3/15
Y1 - 2021/3/15
N2 - The EORTC/MSGERC recently revised and updated the consensus definitions of invasive fungal disease (IFD). These definitions primarily focus on patients with cancer and stem cell or solid-organ transplant patients. They may therefore not be suitable for intensive care unit (ICU) patients. More in detail, while the definition of proven IFD applies to a broad range of hosts, the categories of probable and possible IFD were primarily designed for classical immunocompromised hosts and may therefore not be ideal for other populations. Moreover, the scope of the possible category of IFD has been diminished in the recently revised definitions for classically immunocompromised hosts. Diagnosis of IFD in the ICU presents many challenges, which are different for invasive candidiasis and for invasive aspergillosis. The aim of this article is to review progresses made in recent years and difficulties remaining in the development of definitions applicable in the ICU setting.
AB - The EORTC/MSGERC recently revised and updated the consensus definitions of invasive fungal disease (IFD). These definitions primarily focus on patients with cancer and stem cell or solid-organ transplant patients. They may therefore not be suitable for intensive care unit (ICU) patients. More in detail, while the definition of proven IFD applies to a broad range of hosts, the categories of probable and possible IFD were primarily designed for classical immunocompromised hosts and may therefore not be ideal for other populations. Moreover, the scope of the possible category of IFD has been diminished in the recently revised definitions for classically immunocompromised hosts. Diagnosis of IFD in the ICU presents many challenges, which are different for invasive candidiasis and for invasive aspergillosis. The aim of this article is to review progresses made in recent years and difficulties remaining in the development of definitions applicable in the ICU setting.
KW - biomarker
KW - definition
KW - histology
KW - invasive aspergillosis (IA)
KW - invasive candidiasis (IC)
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U2 - 10.1093/cid/ciaa1751
DO - 10.1093/cid/ciaa1751
M3 - Article
C2 - 33709127
AN - SCOPUS:85102811823
SN - 1058-4838
VL - 72
SP - S121-S127
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
ER -