Epigenetics and first-episode psychosis: A systematic review

Laura Lockwood; Brian Miller; Nagy A. Youssef

doi:10.1016/j.psychres.2021.114325

Epigenetics and first-episode psychosis: A systematic review

Laura Lockwood, Brian Miller, Nagy A. Youssef

Psychiatry and Health Behavior

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Background: Schizophrenia has a large disease burden globally. Early intervention in psychosis, and therefore a decreased duration of untreated psychosis, has a positive clinical impact. There are several recognized risk factors for psychosis, including trauma history and substance use. This systematic review examined the literature for studies related to epigenetic changes in first-episode psychosis, with the goal of identifying future research directions. Methods: A literature review was conducted from inception to October 3, 2021 using MedLine/PubMed, Web of Science, and PsycInfo searches with the keywords ("first-episode schizophrenia" OR "first-episode psychosis" OR "drug-naive schizophrenia" OR "drug-naive psychosis") AND (epigenetic OR methylation OR hydroxymethylation OR "histone modification" OR "miRNA") as well as a search of the bibliography of the identified papers. Results: Seventeen studies that examined various portions of the genome were included in this systematic review. There were two studies that showed hypomethylation at the LINE-1 portion of the genome and two that showed hypermethylation at LINE-1. Additionally, two studies showed hypomethylation specifically at the GRIN2B promoter (part of LINE-1). Conclusions: Although sample sizes were small, these studies provide evidence for epigenetic alterations in early psychosis. Further research in this area is warranted for more definitive epigenetic correlations.

Original language	English (US)
Article number	114325
Journal	Psychiatry Research
Volume	307
DOIs	https://doi.org/10.1016/j.psychres.2021.114325
State	Published - Jan 2022

Keywords

Childhood trauma
Epigenetics
First episode psychosis
Psychosis
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.psychres.2021.114325

Cite this

@article{8e1d7700f2c64148b582fe04acb30dcf,

title = "Epigenetics and first-episode psychosis: A systematic review",

abstract = "Background: Schizophrenia has a large disease burden globally. Early intervention in psychosis, and therefore a decreased duration of untreated psychosis, has a positive clinical impact. There are several recognized risk factors for psychosis, including trauma history and substance use. This systematic review examined the literature for studies related to epigenetic changes in first-episode psychosis, with the goal of identifying future research directions. Methods: A literature review was conducted from inception to October 3, 2021 using MedLine/PubMed, Web of Science, and PsycInfo searches with the keywords ({"}first-episode schizophrenia{"} OR {"}first-episode psychosis{"} OR {"}drug-naive schizophrenia{"} OR {"}drug-naive psychosis{"}) AND (epigenetic OR methylation OR hydroxymethylation OR {"}histone modification{"} OR {"}miRNA{"}) as well as a search of the bibliography of the identified papers. Results: Seventeen studies that examined various portions of the genome were included in this systematic review. There were two studies that showed hypomethylation at the LINE-1 portion of the genome and two that showed hypermethylation at LINE-1. Additionally, two studies showed hypomethylation specifically at the GRIN2B promoter (part of LINE-1). Conclusions: Although sample sizes were small, these studies provide evidence for epigenetic alterations in early psychosis. Further research in this area is warranted for more definitive epigenetic correlations.",

keywords = "Childhood trauma, Epigenetics, First episode psychosis, Psychosis, Schizophrenia",

author = "Laura Lockwood and Brian Miller and Youssef, {Nagy A.}",

note = "Funding Information: Dr. Youssef received research support from Department of Veteran Affairs, Department of Defense, and The Augusta Biomedical Research Corporation, and research support but not salary support from PCORI, MECTA Corporation, Vistagen, and Merck. Dr. Youssef also received Speaker CME honoraria from the Georgia Department of Behavioral Health and Developmental Disabilities (DHBDD) and Psychiatric Annals for unrelated CME topics. Dr. Miller has nothing to disclose for the work under consideration. In the past 12 months, Dr. Miller received research support from Augusta University, the National Institute of Mental Health, and the Stanley Medical Research Institute; participated in Advisory Boards for Boehringer Ingelheim; and Honoraria from Atheneum, Clearview Healthcare Partners, and Psychiatric Times. Dr. Lockwood has nothing to disclose. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting views of the US government or the Department of Defense. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2022",

month = jan,

doi = "10.1016/j.psychres.2021.114325",

language = "English (US)",

volume = "307",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Epigenetics and first-episode psychosis

T2 - A systematic review

AU - Lockwood, Laura

AU - Miller, Brian

AU - Youssef, Nagy A.

N1 - Funding Information: Dr. Youssef received research support from Department of Veteran Affairs, Department of Defense, and The Augusta Biomedical Research Corporation, and research support but not salary support from PCORI, MECTA Corporation, Vistagen, and Merck. Dr. Youssef also received Speaker CME honoraria from the Georgia Department of Behavioral Health and Developmental Disabilities (DHBDD) and Psychiatric Annals for unrelated CME topics. Dr. Miller has nothing to disclose for the work under consideration. In the past 12 months, Dr. Miller received research support from Augusta University, the National Institute of Mental Health, and the Stanley Medical Research Institute; participated in Advisory Boards for Boehringer Ingelheim; and Honoraria from Atheneum, Clearview Healthcare Partners, and Psychiatric Times. Dr. Lockwood has nothing to disclose. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting views of the US government or the Department of Defense. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/1

Y1 - 2022/1

N2 - Background: Schizophrenia has a large disease burden globally. Early intervention in psychosis, and therefore a decreased duration of untreated psychosis, has a positive clinical impact. There are several recognized risk factors for psychosis, including trauma history and substance use. This systematic review examined the literature for studies related to epigenetic changes in first-episode psychosis, with the goal of identifying future research directions. Methods: A literature review was conducted from inception to October 3, 2021 using MedLine/PubMed, Web of Science, and PsycInfo searches with the keywords ("first-episode schizophrenia" OR "first-episode psychosis" OR "drug-naive schizophrenia" OR "drug-naive psychosis") AND (epigenetic OR methylation OR hydroxymethylation OR "histone modification" OR "miRNA") as well as a search of the bibliography of the identified papers. Results: Seventeen studies that examined various portions of the genome were included in this systematic review. There were two studies that showed hypomethylation at the LINE-1 portion of the genome and two that showed hypermethylation at LINE-1. Additionally, two studies showed hypomethylation specifically at the GRIN2B promoter (part of LINE-1). Conclusions: Although sample sizes were small, these studies provide evidence for epigenetic alterations in early psychosis. Further research in this area is warranted for more definitive epigenetic correlations.

AB - Background: Schizophrenia has a large disease burden globally. Early intervention in psychosis, and therefore a decreased duration of untreated psychosis, has a positive clinical impact. There are several recognized risk factors for psychosis, including trauma history and substance use. This systematic review examined the literature for studies related to epigenetic changes in first-episode psychosis, with the goal of identifying future research directions. Methods: A literature review was conducted from inception to October 3, 2021 using MedLine/PubMed, Web of Science, and PsycInfo searches with the keywords ("first-episode schizophrenia" OR "first-episode psychosis" OR "drug-naive schizophrenia" OR "drug-naive psychosis") AND (epigenetic OR methylation OR hydroxymethylation OR "histone modification" OR "miRNA") as well as a search of the bibliography of the identified papers. Results: Seventeen studies that examined various portions of the genome were included in this systematic review. There were two studies that showed hypomethylation at the LINE-1 portion of the genome and two that showed hypermethylation at LINE-1. Additionally, two studies showed hypomethylation specifically at the GRIN2B promoter (part of LINE-1). Conclusions: Although sample sizes were small, these studies provide evidence for epigenetic alterations in early psychosis. Further research in this area is warranted for more definitive epigenetic correlations.

KW - Childhood trauma

KW - Epigenetics

KW - First episode psychosis

KW - Psychosis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85120890409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85120890409&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2021.114325

DO - 10.1016/j.psychres.2021.114325

M3 - Review article

C2 - 34896847

AN - SCOPUS:85120890409

SN - 0165-1781

VL - 307

JO - Psychiatry Research

JF - Psychiatry Research

M1 - 114325

ER -

Epigenetics and first-episode psychosis: A systematic review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this