Epigenetics and MicroRNAs in renal cancer

Shahana Majid; Sharanjot Saini; Guoren Deng; Rajvir Dahiya

doi:10.1007/978-94-007-6612-9_4

Epigenetics and MicroRNAs in renal cancer

Shahana Majid, Sharanjot Saini, Guoren Deng, Rajvir Dahiya

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.

Original language	English (US)
Title of host publication	Epigenetics and Cancer
Publisher	Springer Netherlands
Pages	63-84
Number of pages	22
ISBN (Electronic)	9789400766129
ISBN (Print)	9400766114, 9789400766112
DOIs	https://doi.org/10.1007/978-94-007-6612-9_4
State	Published - Feb 1 2013
Externally published	Yes

Keywords

Epigenetics
MicroRNA
Renal cancer

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-94-007-6612-9_4

Cite this

@inbook{7e30f44099904678af266de19804b68d,

title = "Epigenetics and MicroRNAs in renal cancer",

abstract = "Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.",

keywords = "Epigenetics, MicroRNA, Renal cancer",

author = "Shahana Majid and Sharanjot Saini and Guoren Deng and Rajvir Dahiya",

year = "2013",

month = feb,

day = "1",

doi = "10.1007/978-94-007-6612-9_4",

language = "English (US)",

isbn = "9400766114",

pages = "63--84",

booktitle = "Epigenetics and Cancer",

publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Epigenetics and MicroRNAs in renal cancer

AU - Majid, Shahana

AU - Saini, Sharanjot

AU - Deng, Guoren

AU - Dahiya, Rajvir

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.

AB - Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.

KW - Epigenetics

KW - MicroRNA

KW - Renal cancer

UR - http://www.scopus.com/inward/record.url?scp=84932087426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84932087426&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-6612-9_4

DO - 10.1007/978-94-007-6612-9_4

M3 - Chapter

AN - SCOPUS:84932087426

SN - 9400766114

SN - 9789400766112

SP - 63

EP - 84

BT - Epigenetics and Cancer

PB - Springer Netherlands

ER -

Epigenetics and MicroRNAs in renal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this