Abstract
Epigenetic states are orchestrated by several converging and reinforcing signals, including DNA methylation, histone modifications and non-coding RNAs. Growing evidence indicates that acquired epigenetic abnormalities participate with genetic alterations to cause cancer. In this review we describe recent advances in the field of cancer epigenomics and microRNAs (miRNAs) with special emphasis on renal cancer. We discuss whether epigenetic changes are the cause or consequence of cancer initiation and the use of epigenetic biomarkers and miRNAs for cancer diagnosis or prognosis. Finally we address the potential of epigenetic based anti-cancer therapeutic strategies.
| Original language | English (US) |
|---|---|
| Title of host publication | Epigenetics and Cancer |
| Publisher | Springer Netherlands |
| Pages | 63-84 |
| Number of pages | 22 |
| ISBN (Electronic) | 9789400766129 |
| ISBN (Print) | 9400766114, 9789400766112 |
| DOIs | |
| State | Published - Feb 1 2013 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Epigenetics
- MicroRNA
- Renal cancer
ASJC Scopus subject areas
- General Medicine
Fingerprint
Dive into the research topics of 'Epigenetics and MicroRNAs in renal cancer'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS