Epilepsy and neuropsychological comorbidities

Leslie A. Rudzinski, Kimford J. Meador

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Purpose of Review: Epilepsy is a chronic disorder with several associated comorbidities requiring timely recognition and treatment. This article discusses aspects of cognitive impairment; psychiatric disorders including depression, anxiety, and psychosis; and health-related quality-of-life issues pertaining to patients with epilepsy. Recent Findings: Cognitive problems in epilepsy may be present early in the disease course. Advances in imaging techniques are allowing correlation of structure and function as they relate to cognitive impairment in epilepsy. The relationship between epilepsy, depression, and anxiety is increasingly recognized, and these psychiatric comorbidities may affect suicide risk, patient-reported adverse antiepileptic drug effects, and quality of life. Psychiatric disorders are underrecognized and undertreated in patients with epilepsy. Summary: Physicians who treat patients with epilepsy should be aware of themajor impact that cognitive impairment and psychiatric comorbidities have on these patients. Identifying and treating these comorbidities in epilepsy patients is just as important as seizure treatment.

Original languageEnglish (US)
Pages (from-to)682-696
Number of pages15
JournalCONTINUUM Lifelong Learning in Neurology
Issue number3
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)


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