Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

Koichi Tanaka; Zhonglin Hao; Mihoko Kai; Hiroto Okayama

doi:10.1093/emboj/20.20.5779

Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

Koichi Tanaka, Zhonglin Hao, Mihoko Kai, Hiroto Okayama

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.

Original language	English (US)
Pages (from-to)	5779-5790
Number of pages	12
Journal	EMBO Journal
Volume	20
Issue number	20
DOIs	https://doi.org/10.1093/emboj/20.20.5779
State	Published - Oct 15 2001
Externally published	Yes

Keywords

Cohesin
Eso1p
Fission yeast
Pds5p
Sister chromatid cohesion

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.1093/emboj/20.20.5779

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title = "Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism",

abstract = "During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.",

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T1 - Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

AU - Tanaka, Koichi

AU - Hao, Zhonglin

AU - Kai, Mihoko

AU - Okayama, Hiroto

PY - 2001/10/15

Y1 - 2001/10/15

N2 - During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.

AB - During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.

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KW - Eso1p

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KW - Pds5p

KW - Sister chromatid cohesion

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Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism

Abstract

Keywords

ASJC Scopus subject areas

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