Evaluation of leuprolide acetate treatment on histopathology of uterine myomata

J. N. Gutmann, K. L. Thornton, M. P. Diamond, M. L. Carcangiu

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Objective: To determine if short-term, preoperative leuprolide acetate (LA) therapy alters the histologic appearance of uterine leiomyomata. Design: Retrospective evaluation by a pathologist (who was blinded to patient history) of the histologic features of leiomyomata excised from 36 women, 12 who received preoperative LA and 24 age-matched controls. Setting: Yale-New Haven Hospital, New Haven, Connecticut, from September 1989 to September 1990. Main Outcome Measure: The histologic specimens were evaluated for the presence of mitotic activity, cellular atypia, cellularity, and secondary changes including edema, fibrosis, calcification, hemorrhage, infarction, hyalinization, and vascular appearance. Results: Of the 12 patients treated with LA, 10 (84%) demonstrated a reduction in uterine volume after 3 to 6 months of LA therapy. There was no difference in any of the histopathologic parameters evaluated between the LA-treated group and the untreated group. Exclusion of leiomyoma, which did not have a reduction in size during LA therapy, did not alter the analysis. Among patients treated with LA, those leiomyoma that did not respond to LA had a greater degree of hyalinization than those that responded. Conclusion: Reduction in uterine size by short- term LA therapy did not detectably alter histologic appearance of leiomyoma.

Original languageEnglish (US)
Pages (from-to)622-626
Number of pages5
JournalFertility and sterility
Issue number4
StatePublished - 1994
Externally publishedYes


  • Gonadotropin-releasing hormone analogue
  • histopathology
  • leiomyomata

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


Dive into the research topics of 'Evaluation of leuprolide acetate treatment on histopathology of uterine myomata'. Together they form a unique fingerprint.

Cite this