TY - JOUR
T1 - Exercise and Cognitive Training as a Strategy to Improve Neurocognitive Outcomes in Heart Failure
T2 - A Pilot Study
AU - Gary, Rebecca A.
AU - Paul, Sudeshna
AU - Corwin, Elizabeth
AU - Butts, Brittany
AU - Miller, Andrew H.
AU - Hepburn, Kenneth
AU - Williams, Bryan
AU - Waldrop-Valverde, Drenna
N1 - Funding Information:
This work was supported in part by the National Institutes of Health National Institute of Nursing Research grant 1P30NR014134-01 (PI, DWV) , Advancing Translational Sciences of the National Institutes of Health under award no. UL1TR000454 (D. Stephens). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This study is registered at www.clinicaltrials.gov ( NCT02151266 ). The authors would like to acknowledge Trish Relli-Moniz, B.S., project manager and Becky McElroy, data manager, for her relentless organization and for tracking down all data.
Funding Information:
This work was supported in part by the National Institutes of Health National Institute of Nursing Research grant 1P30NR014134-01 (PI, DWV), Advancing Translational Sciences of the National Institutes of Health under award no. UL1TR000454 (D. Stephens). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This study is registered at www.clinicaltrials.gov (NCT02151266). The authors would like to acknowledge Trish Relli-Moniz, B.S. project manager and Becky McElroy, data manager, for her relentless organization and for tracking down all data.
Publisher Copyright:
© 2019 American Association for Geriatric Psychiatry
PY - 2019/8
Y1 - 2019/8
N2 - Objective: Mild cognitive impairment, especially memory loss, is prevalent in patients with heart failure (HF) and contributes to poor clinical outcomes and higher mortality. Methods: This study evaluated a combined aerobic exercise and cognitive training (EX/CT) program on memory, executive function, attention, processing speed and reaction time compared to exercise only or a usual care attention control (UCAC) stretching and flexibility program. Participants completed a standardized neurocognitive battery at baseline, 3 months, and 6 months along with demographic, clinical, and functional capacity (6-minute walk test). A linear mixed model analysis was used with comorbidity as a covariate. Results: Sixty-nine participants were enrolled, the mean age was 61 ± 10 years, 54% were women, 55% were African American, and the mean left ventricular ejection fraction percentage was 35 ± 15. A significant group by time interaction for verbal memory was found at 3 months (F [2, 53] = 4.3, p = 0.018) but was not sustained at 6 months in the EX/CT group. Processing speed/attention differed across treatment groups between baseline and 6 months, but improvement occurred among UCAC participants. There were also significant group differences in the 6MWT distance occurring at 3 months (F [2, 52] = 3.5, p = 0.036); however, significant improvement was observed within the EX/CT group only. There were no significant differences in 6MWT in the other groups at 3 or 6 months. Conclusion: An EX/CT intervention was associated with improved memory in persons with HF and warrants further investigation in a larger trial. The relationship between functional capacity and cognitive function also needs further study.
AB - Objective: Mild cognitive impairment, especially memory loss, is prevalent in patients with heart failure (HF) and contributes to poor clinical outcomes and higher mortality. Methods: This study evaluated a combined aerobic exercise and cognitive training (EX/CT) program on memory, executive function, attention, processing speed and reaction time compared to exercise only or a usual care attention control (UCAC) stretching and flexibility program. Participants completed a standardized neurocognitive battery at baseline, 3 months, and 6 months along with demographic, clinical, and functional capacity (6-minute walk test). A linear mixed model analysis was used with comorbidity as a covariate. Results: Sixty-nine participants were enrolled, the mean age was 61 ± 10 years, 54% were women, 55% were African American, and the mean left ventricular ejection fraction percentage was 35 ± 15. A significant group by time interaction for verbal memory was found at 3 months (F [2, 53] = 4.3, p = 0.018) but was not sustained at 6 months in the EX/CT group. Processing speed/attention differed across treatment groups between baseline and 6 months, but improvement occurred among UCAC participants. There were also significant group differences in the 6MWT distance occurring at 3 months (F [2, 52] = 3.5, p = 0.036); however, significant improvement was observed within the EX/CT group only. There were no significant differences in 6MWT in the other groups at 3 or 6 months. Conclusion: An EX/CT intervention was associated with improved memory in persons with HF and warrants further investigation in a larger trial. The relationship between functional capacity and cognitive function also needs further study.
KW - Heart failure
KW - cognitive training
KW - exercise
KW - mild cognitive impairment
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U2 - 10.1016/j.jagp.2019.01.211
DO - 10.1016/j.jagp.2019.01.211
M3 - Article
C2 - 30910420
AN - SCOPUS:85063113935
SN - 1064-7481
VL - 27
SP - 809
EP - 819
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 8
ER -
