Exercise and weight loss improve exercise capacity independent of cardiac function in metabolic syndrome

Anand Chockalingam; Melissa A. Linden; Marc Del Rosario; Gurushankar Govindarajan; Kevin C. Dellsperger; Tom R. Thomas

doi:10.1177/0003319709336418

Exercise and weight loss improve exercise capacity independent of cardiac function in metabolic syndrome

Anand Chockalingam, Melissa A. Linden, Marc Del Rosario, Gurushankar Govindarajan, Kevin C. Dellsperger, Tom R. Thomas

Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO_2max five days/week (∼-375 kcal/session) and caloric restriction (∼-600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 ± 1y, women = 6, BMI = 33.5 ± 1.0 kg/m²) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO_2max, resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 ± 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO_2max increases significantly with lifestyle while cardiac function remains unchanged.

Original language	English (US)
Pages (from-to)	192-197
Number of pages	6
Journal	Angiology
Volume	61
Issue number	2
DOIs	https://doi.org/10.1177/0003319709336418
State	Published - Feb 2010

Keywords

Diastolic function
E/E'
Exercise capacity
Lifestyle changes
Metabolic syndrome
Weight loss

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/0003319709336418

Cite this

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title = "Exercise and weight loss improve exercise capacity independent of cardiac function in metabolic syndrome",

abstract = "Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO2max five days/week (∼-375 kcal/session) and caloric restriction (∼-600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 ± 1y, women = 6, BMI = 33.5 ± 1.0 kg/m2) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO2max, resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 ± 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO2max increases significantly with lifestyle while cardiac function remains unchanged.",

keywords = "Diastolic function, E/E', Exercise capacity, Lifestyle changes, Metabolic syndrome, Weight loss",

author = "Anand Chockalingam and Linden, {Melissa A.} and {Del Rosario}, Marc and Gurushankar Govindarajan and Dellsperger, {Kevin C.} and Thomas, {Tom R.}",

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AU - Chockalingam, Anand

AU - Linden, Melissa A.

AU - Del Rosario, Marc

AU - Govindarajan, Gurushankar

AU - Dellsperger, Kevin C.

AU - Thomas, Tom R.

PY - 2010/2

Y1 - 2010/2

N2 - Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO2max five days/week (∼-375 kcal/session) and caloric restriction (∼-600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 ± 1y, women = 6, BMI = 33.5 ± 1.0 kg/m2) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO2max, resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 ± 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO2max increases significantly with lifestyle while cardiac function remains unchanged.

AB - Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO2max five days/week (∼-375 kcal/session) and caloric restriction (∼-600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 ± 1y, women = 6, BMI = 33.5 ± 1.0 kg/m2) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO2max, resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 ± 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO2max increases significantly with lifestyle while cardiac function remains unchanged.

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KW - E/E'

KW - Exercise capacity

KW - Lifestyle changes

KW - Metabolic syndrome

KW - Weight loss

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Exercise and weight loss improve exercise capacity independent of cardiac function in metabolic syndrome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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