Exercise and weight loss improve exercise capacity independent of cardiac function in metabolic syndrome

Anand Chockalingam, Melissa A. Linden, Marc Del Rosario, Gurushankar Govindarajan, Kevin C. Dellsperger, Tom R. Thomas

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO2max five days/week (∼-375 kcal/session) and caloric restriction (∼-600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 ± 1y, women = 6, BMI = 33.5 ± 1.0 kg/m2) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO2max, resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 ± 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO2max increases significantly with lifestyle while cardiac function remains unchanged.

Original languageEnglish (US)
Pages (from-to)192-197
Number of pages6
Issue number2
StatePublished - Feb 2010


  • Diastolic function
  • E/E'
  • Exercise capacity
  • Lifestyle changes
  • Metabolic syndrome
  • Weight loss

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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