Exploiting urazole’s acidity for fabrication of hydrogels and ion-exchange materials

Saltuk B. Hanay, Ali Fallah, Efsun Senturk, Zeliha Yetim, Ferdows Afghah, Hulya Yilmaz, Mustafa Culha, Bahattin Koc, Ali Zarrabi, Rajender S. Varma

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole containing gel. The formation of urazole was confirmed by FT-IR and1 H-NMR spectroscopy. The hydrogel was characterized by microscopy imaging as well as spectroscopic and thermo-gravimetric analyses. Mechanical analysis and cell viability tests were performed for its initial biocompatibility evaluation. The prepared hydrogel is a highly porous hydrogel with a Young’s modulus of 0.91 MPa, has a swelling ratio of 87%, and is capable of exchanging ions in a medium. Finally, a general strategy was demonstrated to embed urazole groups directly into a crosslinked material.

Original languageEnglish (US)
Article number261
Issue number4
StatePublished - Dec 2021
Externally publishedYes


  • Biomaterials
  • Hydrogels
  • Ion-exchange
  • Porous gels
  • Urazole

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Polymers and Plastics


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