TY - JOUR
T1 - Expression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients
T2 - a pilot study
AU - Miranda Galvis, Marisol
AU - Freitas Jardim, Juscelino
AU - Kaminagakura, Estela
AU - Santos-Silva, Alan Roger
AU - Paiva Fonseca, Felipe
AU - Paes Almeida, Oslei
AU - Ajudarte Lopes, Marcio
AU - Lópes Pinto, Clóvis
AU - Kowalski, Luiz Paulo
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Objective: Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods: A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results: The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion: No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA–positive and HR-HPV DNA–negative OSCC affecting young patients.
AB - Objective: Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods: A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results: The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion: No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA–positive and HR-HPV DNA–negative OSCC affecting young patients.
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U2 - 10.1016/j.oooo.2018.01.003
DO - 10.1016/j.oooo.2018.01.003
M3 - Article
C2 - 29501355
AN - SCOPUS:85042598448
SN - 2212-4403
VL - 125
SP - 317
EP - 325
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 4
ER -
