TY - JOUR
T1 - Expression of co-stimulatory molecules on langerhans cells in lesional epidermis of human atopic dermatitis
AU - Fesenkova, Valentyna I.
AU - Kurchenko, Anita I.
AU - Castellani, Maria Luisa
AU - Conti, Pio
AU - Anogeianaki, Antonia
AU - Caraffa, Auro
AU - Kalogeromitros, Dimitris
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.
AB - Langerhans cells (LC) are immature dendritic cells (DC) present in the skin epithelium. To understand the molecular and cellular mechanisms governing the inflammatory reaction in atopic dermatitis (AD), the expression of the LC specific marker CD1a, a member of major histocompatibility (MHC)-like glycoproteins, and the co-stimulatory molecules CD80 and CD86, expressed on functionally mature dendritic cells, were counted in lesional biopsies and normal epidermis by an immunohistochemical method. CD1a specific staining was observed in both normal and AD lesion specimens. CD80 and CD86 positive cells with morphological characteristics of the LC were found in lesional AD epidermis, suggesting a high level of functional maturity of these cells and their involvement in chronic inflammatory disease.
KW - Atopic Dermatitis
KW - CD1a
KW - CD80
KW - CD86
KW - Dendritic cell
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U2 - 10.1080/08923970701675101
DO - 10.1080/08923970701675101
M3 - Article
C2 - 18075860
AN - SCOPUS:37149003666
SN - 0892-3973
VL - 29
SP - 487
EP - 498
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
IS - 3-4
ER -