@article{1c3d29521e304c4eb602160ce7091c05,
title = "Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells",
abstract = "T lymphoma cells may constitutively express PD-1 and PD-L1. The relative role of PD-1 and PD-L1 in T lymphoma is incompletely understood. We report here that PD-1+ PDL-1+ human T lymphoma cells exhibit constitutive hyperactivation of the TCR signaling and do not respond to PD-L1-mediated suppression in vitro. Knocking out PD-1 or PD-L1 has no effects on T lymphoma cell apoptosis and proliferation in vitro, but significantly increased tumor-bearing mouse survival. Our findings determine that the constitutively active TCR signaling pathway maintain T lymphoma cell growth in vitro and that both PD-1 and PD-L1 promote T lymphoma growth in vivo.",
keywords = "PD-1, PD-L1, T cell receptor, T lymphoma",
author = "Liu, {Maria Y.} and Klement, {John D.} and Langan, {Candace J.} and {van Riggelen}, Jan and Kebin Liu",
note = "Funding Information: We thank Ms. Jennifer Parks and Susan Dewes at Augusta Shepeard Community Blood Bank for providing blood samples from heathy donors. We also thank Dr. Jeanene Pihkala at Georgia Cancer Center Flow Cytometry Core Facility for assistance in cell sorting. The animal study was conducted according to the approved protocol by Augusta University Institutional Animal Care and Use Committee (Protocol # 2008-0162). Funding Information: This research was funded by National Institutes of Health, R01 CA133085, R01CA227433 (to K.L), and F30CA236436 (to J.D.K). Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = aug,
doi = "10.1016/j.cellimm.2021.104397",
language = "English (US)",
volume = "366",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
}