Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing

Donald C. Aduba; Seon Sook An; Gretchen S. Selders; Juan Wang; W. Andrew Yeudall; Gary L. Bowlin; Todd Kitten; Hu Yang

doi:10.1002/jbm.a.35783

Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing

Donald C. Aduba, Seon Sook An, Gretchen S. Selders, Juan Wang, W. Andrew Yeudall, Gary L. Bowlin, Todd Kitten, Hu Yang

Oral Biology & Dx Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.

Original language	English (US)
Pages (from-to)	2456-2465
Number of pages	10
Journal	Journal of Biomedical Materials Research - Part A
Volume	104
Issue number	10
DOIs	https://doi.org/10.1002/jbm.a.35783
State	Published - Oct 1 2016

Keywords

Kirby-Bauer disk diffusion susceptibility test
arabinoxylan
polysaccharide
silver dressing
wound healing

ASJC Scopus subject areas

Ceramics and Composites
Biomaterials
Biomedical Engineering
Metals and Alloys

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10.1002/jbm.a.35783

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title = "Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing",

abstract = "Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.",

keywords = "Kirby-Bauer disk diffusion susceptibility test, arabinoxylan, polysaccharide, silver dressing, wound healing",

author = "Aduba, {Donald C.} and An, {Seon Sook} and Selders, {Gretchen S.} and Juan Wang and {Andrew Yeudall}, W. and Bowlin, {Gary L.} and Todd Kitten and Hu Yang",

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year = "2016",

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doi = "10.1002/jbm.a.35783",

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T1 - Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing

AU - Aduba, Donald C.

AU - An, Seon Sook

AU - Selders, Gretchen S.

AU - Wang, Juan

AU - Andrew Yeudall, W.

AU - Bowlin, Gary L.

AU - Kitten, Todd

AU - Yang, Hu

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.

AB - Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development.

KW - Kirby-Bauer disk diffusion susceptibility test

KW - arabinoxylan

KW - polysaccharide

KW - silver dressing

KW - wound healing

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Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing

Abstract

Keywords

ASJC Scopus subject areas

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