Abstract
A Facile synthetic approach is reported towards 4-hydroxyquinazoline-4-carboxamides 13a-i through ring expansion of 2,3-dioxoindoline-1-carboxamides 10a-c during secondary amine 11a-d nucleophilic reaction. Single crystal X-ray studies of 10c and 13d support the structures. Some of the synthesized quinazolinecarboxamides 13 show promising vasorelaxant properties with potency higher than that of Doxazosin through the pre-contracted (norepinephrine hydrochloride) rat aorta standard bioassay. Good molecular models (2D-QSAR, pharmacophore) describe the biological observations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28534-28540 |
| Number of pages | 7 |
| Journal | RSC Advances |
| Volume | 9 |
| Issue number | 49 |
| DOIs | |
| State | Published - 2019 |
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
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