Failure of a glass ionomer to remineralize apatite-depleted dentin

Y. K. Kim, C. K.Y. Yiu, J. R. Kim, L. Gu, S. K. Kim, R. N. Weller, D. H. Pashley, F. R. Tay

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IX GP, and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1-4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalJournal of Dental Research
Issue number3
StatePublished - Mar 2010


  • Apatite
  • Demineralized dentin
  • Glass-ionomer cement
  • Ion diffusion.
  • Remineralization

ASJC Scopus subject areas

  • Dentistry(all)


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