Abstract
Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug.
Original language | English (US) |
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Pages (from-to) | 659-663 |
Number of pages | 5 |
Journal | Experimental Neurology |
Volume | 83 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience