Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts

Andrew A. Zalewski, Adarsh K. Gulati

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47 Scopus citations


Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalExperimental Neurology
Issue number3
StatePublished - Mar 1984
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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